IL4 and allergic respiratory disease: In contrast, spleen cells isolated from BALB/c mice in vitro co-cultured individually with LAB strains (L. casei Lc2w (Lc), L. plantarum CCFM47 (Lp), and L. acidophilus CCFM137 (La)) showed reduced IL-4 production by spleen cells exposed to La only, while parallel animal studies displayed LAB-induced alleviation of inflammation post airway allergy for all strains through increased Treg cells and modulation of Th1/Th2 balance [47].