Among the six ccRCC control cases, 3/6 cases (50%) showed expected VHL mutations and a coherent IHC profile (CK7−/AMACR−;CAIX+); one (s16%) had consistent IHC profile, but it was wild type for all the genes in the panel, and two (33%) displayed consistent IHC profile, and harbored mutations either in p53 (splicing site exon 5, IVS5+3>A) or the cKIT (splicing site exon 10, c.1594G>A (p.Val532Ile) genes (Figure 2). Here, VHL is linked to nonpapillary renal cell carcinoma.