Stochastic models of the genome-wide genetic and epigenetic network (GEN) in human cells based on molecular mechanisms, including transcription factor regulation, miRNA repression, DNA methylation and protein–protein interactions (PPIs) have shown that the hepatocarcinogenesis associated with NAFLD and NASH is induced by DNA methylation of histone cluster 2 H2B family member E (HIST2H2BE), heat shock protein family B (small) member 1 (HSPB1), ribosomal protein L30 (RPL30), aldolase, fructose-bisphosphate B (ALDOB), and the regulation of miR-21 and miR-122 [112]. This evidence concerns the gene HSPB1 and metabolic dysfunction-associated steatotic liver disease.