Altered patterns of NASH-specific and NASH-related HCC-specific DNA methylation that were not evident in virus-infected noncancerous samples or 37 samples of HCC associated with either HBV or HCV infection were observed in certain tumor-related genes, such as nuclear receptor binding SET domain protein 2 (NSD2/WHSC1), and are frequently associated with mRNA expression abnormalities [111]. This evidence concerns the gene NSD2 and metabolic dysfunction-associated steatohepatitis.