Subsequent investigations shed light on the effect of coilin on the infection by TRV [24]: the TRV-encoded silencing suppressor 16K physically associates with coilin and triggers its re-localization from CBs to the nucleolus, a change that is potentially perceived by the plant, since it correlates with the activation of salicylic acid (SA) accumulation and signaling. This evidence concerns the gene COIL and infection.