In postmenopausal women with T2DM, one-year isoflavone intake (100 mg of aglycones) was found to improve insulin sensitivity and lipid profiles [135], while three-month supplementation with 132 mg isoflavones was not found to result in a decrease of plasma glycated hemoglobin A1c (HbA1c), blood glucose, or insulin levels [136]. This evidence concerns the gene INS and type 2 diabetes mellitus.