CASP8 and gastric neoplasm: Additionally, some triterpenes demonstrated cytotoxicity in several cells such as colon and stomach cancer cells, inducing apoptosis via extrinsic and intrinsic pathways and activating caspase-8, -9, and -3 [23], and HEp-2, HCT 116, MCF-7, A-549, and PC-3 cancer cells [24].