In the current study, we reveal that Ly6Clow monocyte recruitment to the brain was mainly mediated by the interaction of VCAM1 expressed on endothelial cells and VLA4 expressed on the monocytes following infection with C. neoformans. This is in contrast to steady condition in which crawling of Ly6Clow monocytes along endothelial cells of dermis is mediated by CD11a [7]. This evidence concerns the gene ITGAL and infection.