Although miR-548 has not been reported in CNS tumors including PCNSL, the miR-548 acts as an anti-oncogenic factor inhibiting the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway in lung cancer [36] and associated with high-risk Gleason scores in prostate cancer [37]. The gene discussed is AKT1; the disease is primary central nervous system lymphoma.