For example, human epidermal growth factor receptor 3 (HER‐3) binding aptamer and MUC1 aptamer were used to simultaneously detect MUC1 protein and HER‐3 receptor on the surface of breast cancer cells, which not only kept the probe stable in the complex system, but also had good selectivity and sensitivity for the detection of MCF‐7 cells. This evidence concerns the gene MUC1 and breast carcinoma.