F10 and Stroke: Comparable findings were reported for the pivotal Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation (ENGAGE-AF) study38 of edoxaban vs warfarin and Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial39 of rivaroxaban vs warfarin in AF.