Interestingly, unlike skin and lung fibrosis, dramatically increased hepatic expression of RXFP1 has been observed in a rat model of liver cirrhosis and—in contrast to lung and skin‐‐higher expression of RXFP1 is correlated with increased liver fibrosis in human (Fallowfield et al., 2014; McBride et al., 2017; Nagorniewicz et al., 2019). This evidence concerns the gene RXFP1 and Hepatic fibrosis.