We chose to analyze a subset of previously reported MiT/TFE family protein‐targeting genes (Martina et al., 2014; Settembre et al., 2011; Xia et al., 2016), and our results showed that the transcriptional expression levels of many autophagosomal and lysosomal genes, but not the genes associated with ALS/FTD, were up‐regulated in C9orf72‐deficient cells (Figure 6b and Figure S6). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.