Recent study confirmed that various long non‐coding RNAs (lncRNAs) regulated pathological and physiological process of colon cancer.8, 9, 10 LncRNA POU6F2‐AS2 was a novel biomarker which affected the occurrence and development of oesophageal cancer.11 In addition, it could interact with Ybx1 and further participate in development of oesophageal squamous cell carcinoma.12 The molecular mechanism of lncRNA POU6F2‐AS2, regulated genes and pathways in colon cancer was unclear so far. The gene discussed is YBX1; the disease is colonic neoplasm.