It was found to interact with Ybx1 protein and also participated in DNA damage response and regulation of cell survival.20 In gastric cancer, high expression of POU6F2‐AS2 is related to depth of tumour invasion and TNM stage.21 Based on lncRNA‐mRNA interactive network constructed by ping‐pang algorithm, Lv et al11 found that lncRNA POU6F2‐AS2 was associated with the occurrence and development of oesophageal cancer. This evidence concerns the gene YBX1 and carcinoma of esophagus.