MAP3K7 and malignant colon neoplasm: In malignant melanoma, the expression of miR‐377 was silenced, E2F and MAP3K7/NF‐κB signalling pathway were activated, and metastatic and tumorigenic potentials were promoted.22 Hiroshi et al23 processed gene expression microarray and Western blot analysis, and found that E2F pathway was down‐regulated in colon cancer cells.