In previous studies, enhanced expression of P‐gp was confirmed to participate in DNA repair progress, which was critical for cisplatin resistance in colon adenocarcinoma cell lines.32 Besides, ABC transporter MRP2 was higher expressed in various human cisplatin‐resistant cell lines.33 Based on Sakai et al,34 inherent mutations of BRCA2 might induce resistance to cisplatin in breast and ovarian cancers. Here, PGP is linked to colon adenocarcinoma.