Consistent with our research, BRD4 has been confirmed to involve in cell proliferation and cycle progression,16 and BRD4 inhibitor significantly inhibited cell metastasis and growth of colon cancer.29 Consequently, lncRNA POU6F2‐AS2 promoted cell proliferation by regulating miR‐377/BRD4 gene. The gene discussed is BRD4; the disease is malignant colon neoplasm.