When NFER is engulfed by cancer cells, the nanosystem can release erastin and rapamycin, inhibiting system Xc‐ and autophagy, respectively, and eventually causing cell death via ferroptosis.10 In addition, a metal−organic network (MON) encapsulating p53 plasmid (MON‐p53) and combined with ferric ions can also induce ferroptosis by releasing iron and p53 plasmid to inhibit system Xc‐. This evidence concerns the gene TP53 and cancer.