In addition, the increased serum level of IL‐4 has been reported in children with complicated Plasmodium falciparum infection, compared with uncomplicated children.(21) Moreover, the increased production of IL‐4 related to the severity of falciparum malaria parasitemia,(22) its protective role against Mycoplasma pulmonary diseases,(23) and its increased level associated with the increased severity of asthma(24) have been reported in the literatures. This evidence concerns the gene IL4 and asthma.