There are two longitudinal studies investigating systemic apolipoproteins and the progression of AMD.111, 219 Only one of these studies found that systemic ApoA1 levels, the major structural protein component of HDL, are associated with an increased risk of developing late AMD, while systemic ApoB levels, the primary apolipoproteins of the other four lipoproteins, are associated with a decreased risk for developing early AMD over 14 years follow‐up.111. This evidence concerns the gene APOA1 and age-related macular degeneration.