FMR1 and fragile X syndrome: For example, CGG repeats occurring at the 5′-UTR of FMR1 gene is associated with diseases, such as fragile X syndrome (FXS) and fragile X-associated tremor ataxia syndrome (FXTAS) (59), while recent reports have linked TGG repeats mediated microdeletion at human chromosome 14q32.2 with Kagami-Ogata syndrome (60,61).