Two patients had a high level of iron overload (>79 μmol/g [27]) – one was a 55-year-old male patient whose MRI showed a concentration of 280 μmol/g of iron in the liver, with ferritin at 1813 ng/mL and transferrin saturation at 47.3% (RV 20–45%), steatosis, and a heterozygous c.845G>A, p.Cys282Tyr variant in HFE gene. Here, TF is linked to Tangier disease.