The most significantly increased protein correlated with circ‐MALAT1 overexpression was found to be Janus‐activated kinase 2 (JAK2), a well‐characterized protein that could induce CSC‐like characteristics (Figure 3C).29, 30, 31 Conversely, Paired box 5 (PAX5), a tumor suppressor, decreased most significantly after circ‐MALAT1 overexpression among the 5 proteins (PAX5, ACTA1, ARFIP1, CLDN5, and KRT18) out of the 10 downregulated proteins in HCC cells (Figure 3D). This evidence concerns the gene PAX5 and hepatocellular carcinoma.