In particular, the exosomal PCA3/PRAC value was significantly higher in the high-grade prostate cancer group (GS ≥ 7) than that in the biopsy-negative group (p=0.017), while PCA3/PRAC was comparable between low-grade and biopsy-negative groups (Figure 1(f)). This evidence concerns the gene PRAC1 and Familial prostate cancer.