To date, only mipomersen, a second-generation ASO against the coding region of human apoB mRNA (nucleotides 3249–3269), has been approved by the US FDA as an adjunct to diet and statins for lowering LDL-C, apoB, total cholesterol, and nonHDL-C for the treatment of homozygous FH (HoFH) [211]. Here, APOB is linked to familial hyperaldosteronism.