The down-regulated pathways include “Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)”, “Electric Transmission across Gap Junctions”, “Signaling by TGF-beta Receptor Complex”, “Bacterial invasion of epithelial cells”, “Macroautophagy”, and “Intraflagellar transport”. The gene discussed is AVPR2; the disease is Central diabetes insipidus.