In the previous reports, the association of poor MPNST prognosis with NF1 is also highly controversial; although studies have shown that MPNST patients with NF1 had poorer prognosis than those without NF1 [40], meta-analyses of more than 1,800 patients with MPNST suggested that their survival did not depend on the presence of NF1 [41]. Here, NF1 is linked to malignant peripheral nerve sheath tumor.