SPRY2 and metastatic neoplasm: However, the only recurrent clonal driver mutation shared between primary and metastatic HGSOC was TP53. Interestingly, a higher driver mutation rate of 35% was observed in patient OVA_047 with a clonal TP53 mutation in addition to subclonal copy number loss in primary tumours, contributing to the prevalent instability in HGSOC as previously reported.33,34 Other clonal mutations observed in both primary and metastatic tumours were seen in KDM5C and SPRY2 genes suggesting their sustained involvement in tumour initiation and maintenance or progression.