CDK6 and metastatic neoplasm: Interestingly, although case OVA_365 did not present any primary tumour-specific or shared actionable genes, it did present with one shared actionable IGF1R amplification between its contralateral ovary and distant metastasis, with an additional four actionable gene amplifications in MYC, ALK, CCND3 and CDK6, specific to its distant metastatic tumour.