Other mutations included KDM5C (1/6, OVA_013), FLNA (1/6, OVA_378), RGS7 (1/6, OVA_047) and SPRY2 (1/6, OVA_365), which were also clonal in both primary and metastatic tumours. The gene discussed is SPRY2; the disease is metastatic neoplasm.