On the other hand, clonal mutations in ARNT (OVA_047), NTRK1 (OVA_048), MYH9 (OVA_047) and PPARG (OVA_047), and subclonal mutations in ITGAV (OVA_047) and PTPRT (OVA_003) were all specific to metastatic tumours (Figs. 1c and 2). This evidence concerns the gene ITGAV and metastatic neoplasm.