Crago et al. performed whole-exome sequencing of DTF and demonstrated additional genomic alterations in association with the canonical Wnt/β-catenin signaling pathway (i.e. loss of chromosome 6 or BMI1 mutations), further substantiating the idea that β-catenin is the major oncogenic driver in desmoid tumor development and progression. Here, BMI1 is linked to desmoid tumor.