MTDH and neoplasm: As expected, anti-PSAP and anti-LYRIC antibodies detected the related proteins considerably more in live than in apoptotic tumor cells by IHC analysis (Supplementary Fig. 3), in agreement with the rule that antibodies generally recognize the native (folded) proteins rather than the corresponding fragmented (unfolded) forms that, vice versa, are more efficiently processed and presented to T cells by antigen-presenting cells (APCs)31, such as those we found upregulated in apoptotic tumor cells by SILAC-based proteomics.