Visual functional improvement following topical NGF treatment has been reported in patients, including three glaucoma patients assessed by pattern electroretinogram (PERG) and visual evoked potentials (VEPs)26, one patient with age-related macular degeneration (AMD) by visual acuity and focal ERG49, and five children with optic glioma and optic nerve atrophy by VEP50. Here, NGF is linked to age-related macular degeneration.