In the context of the present results, dogs subjected to allergen-specific immunotherapy for atopic dermatitis produced IgG antibodies (isotype not specified) against a 98 kDa D. farinae molecule, presumed to be Der f 1584 and specific immunotherapy with whole bee venom resulted in an increase in the ratio of anti-PLA2 IgG4:IgE in serum85. This evidence concerns the gene IGHE and atopic eczema.