Obesity parameters include percentage of fat39, TG, TC40, ALT, AST41, leptin42, adipogenesis (SREBP-1, C/EBPα, PPARγ)43, and lipogenesis related genes (SREBP-1, C/EBPα, LXRα)44. The gene discussed is NR1H3; the disease is obesity due to melanocortin 4 receptor deficiency.