Consistent with all these observations, we found that the COPD correlation network built by SWIM software consists of three well-characterized modules: one populated by switch genes all up-regulated in COPD cases and related to the regulation of immune and inflammatory response; one populated by well-recognized immune signature genes all up-regulated in COPD cases; and one where the GWAS gene AGER and CAVIN1 are the most representative module genes, both down-regulated in COPD cases. Here, AGER is linked to chronic obstructive pulmonary disease.