SIRT1 and breast cancer: A recent study of Egyptian women found a positive association between SIRT1 rs12778366 TT genotype and the risk of breast cancer as compared to TC and CC genotypes, and carrying the rs12778366 TT genotype was associated with higher serum SIRT1 levels compared to TC and CC genotypes in breast cancer cases but not controls, while, overall, breast cancer cases had significantly higher serum SIRT1 levels than controls42.