SIRT1 and malignant colon neoplasm: We found that rs12778366 CC versus TT genotype decreased CRC and colon cancer risks in women (HR for CRC = 0.53, 95% confidence interval: 0.30–0.94) but not men using 20.3 years of follow-up, but no conclusions could be made as regards to a possible interaction between SIRT1 variants and metabolic risk factors as the direction of associations was not always conform hypothesis nor in the same genotype stratum19.