Consistent with a growing number of studies that have reported the involvement of FKBP5-associated genetic or epigenetic regulation in PTSD16,19, our proof-of-concept study found that altered expression levels of a series of candidate miRNAs derived from FKBP5 KO mice may relate to the compensatory or pathological adaptations of the prefrontolimbic circuit, a major neural correlate of PTSD. Here, FKBP5 is linked to post-traumatic stress disorder.