RUNX1 and acute myeloid leukemia: Familial platelet disorder with predisposition to myeloid malignancy (FPDMM) is normally associated with germline RUNX1 variants and characterized by life-long moderate thrombocytopenia and platelet function defects with heterogeneity both in age and presentation and significant risk of MDS/AML transformation, estimated at 20–60%8.