Patients with heterozygous DHX34 variants had no extra-hematopoietic abnormalities and no acquired variants in any of the 33 genes frequently mutated in MDS/AML analyzed by targeted sequencing, apart from an ASXL1 frameshift insertion (p.Gly646Trpfs*12) (VAF 12.7% and ExAC frequency of 0.0016) identified in the index case (II.1) of family FML061. This evidence concerns the gene ASXL1 and acute myeloid leukemia.