SH2D1B and Behcet disease: As in eat-2 mutants and BD animals, phm-2 mutants show all the characteristics of DR in worms, such as extended lifespan (Fig. 3a, Supplementary Data 2), small and thin-transparent morphology (Supplementary Fig. 3a), reduced brood sizes (Supplementary Fig. 3b) and delayed reproductive output (Supplementary Fig. 3c).