DNMT3A and glioblastoma: Consequently, DNMT3A/AGO4 is also involved in the cytosine methylation of miRNA-451a and miRNA-193a-5p as these parameters are correlated in a cohort of 32 GBM patients and the siRNA-mediated invalidation of DNMT3A or AGO4 decreased the percentage of methylated miRNA-451a and miRNA-193a-5p.