GH1 and acromegaly: The EPPG (European pituitary pathology group) proposed the term of somatotroph plurihormonal PIT1-positive tumor to define lesions with acromegaly/gigantism that show variable expression of PIT1, GH, TSH and/or PRL and thyrotroph plurihormonal PIT1-positive tumors to define those presenting with central hyperthyroidism [13,47].