In the honey bee experiments described herein, SINV-GFP infection induced expression of hsc70-3 over mock-infection in all three biological replicates (i.e., rep1, 1.76 fold, p = 6.8 × 10−5; rep2, 3.07 fold, p = 0.00013; rep3, 2.66 fold, p = 6.8 × 10−5). The gene discussed is CHM; the disease is infection.