Many moderate penetrance genes, as well as BRCA1/2, are associated with homologous recombination DNA repair defects and they are most commonly observed in HGSCs [122], hence, effective screening methods are needed to detect precursor lesions during a window period between the development of a STIC and initiation of invasive carcinoma, 6–7 years [123,124]. This evidence concerns the gene BRCA1 and invasive carcinoma.