ERBB2 and cancer: ADAM10 is the major source of human epidermal growth factor receptor 2 (HER2) ectodomain shedding activity in HER2-overexpressing breast cancer cells [137,138], and is known to promote cancer cell migration [39,41], invasiveness [42] and metastasis [40] in several contexts of cancer progression, as well as in brain glioma [139].