Preliminary PET/CT imaging studies with [<sup>18</sup>F]FPEB were conducted in a transgenic model of Alzheimer's Disease (AD) using B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J (APP/PS1) mice, and data were compared with age-matched wild-type (WT) B6C3F1/J control mice. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.