On the other hand, overexpression of a phosphomimetic moesin mutant attenuates spontaneous autoimmunity in Rap-1-deficient mice by reducing the number of inflammatory T lymphocytes recruited to the colon, whereas T lymphocytes infiltrating inflamed kidneys from systemic lupus erythematosus (SLE) patients show high levels of ERM phosphorylation [86,142]. Here, MSN is linked to systemic lupus erythematosus.