In oesophageal cancer, LYPD3 is regulated via CREB (cAMP response element binding protein) transcription co-activator signalling [61], and therefore, it is postulated that norepinephrine regulates LYPD3 through an ADRβ2/cAMP/PKA/CREB/LYPD3 effector pathway [45]. The gene discussed is CREB1; the disease is carcinoma of esophagus.