Prdx5 deficiency leads to increased susceptibility to high-fat-diet-induced obesity, and thus Prdx5-knockout mice fed a high-fat diet show several metabolic abnormalities, including increased body weight, adipocyte hypertrophy, fat accumulation in the liver, hepatic steatosis, and an increased triglyceride level in the serum [94,96]. The gene discussed is PRDX5; the disease is fatty liver disease.