CASP1 and familial Mediterranean fever: MCs are hypothesized to mediate autoinflammation through NLRP3 inflammasome sensing of extracellular threats; mutations to the NLRP3 inflammasome and its mediators leads to monogenic diseases such as familial Mediterranean fever (FMF) and cryopyrin-associated periodic syndrome (CAPS) which arise from exuberant caspase-1 activity leading to downstream IL-1β secretion and subsequent inflammation [70].