As Cl-amdine showed different effects on LN18 and LN229 GBM cells and due to the fact that it is a pan-PAD inhibitor with inhibitory effects on PAD2, PAD3 and PAD4 isozymes [39], further studies on assessing PAD2, PAD3 and PAD4 isozyme-specific inhibitors in these two GBM cell lines are warranted. The gene discussed is PADI3; the disease is glioblastoma.