Of the selected three which also displayed good brain uptake, fast brain clearance, high affinity for NFT (Table 3) and excellent selectivity against Aβ plaques in AD brain tissue, lower affinity for MAO-A and MAO-B in comparison to [18F]T807 and [18F]THK-5351, and based on preclinical binding study RO-948 was selected for further development. The gene discussed is MAOA; the disease is Alzheimer disease.