Following the observation that ligands with a π-electron-conjugated backbone longer than 13Å showed affinities for pathological inclusions in a several tauopathies Maruyama et al. investigated the affinities of a series of compounds with a different structural dimension to tau aggregates and concluded that a core structure with specific distance from 13–19 Å contributes to affinity for non-AD inclusions. Here, MAPT is linked to Alzheimer disease.