It not only displayed a quicker white matter washout (lower white matter retention) and higher specific binding to AD tau-associated regions of interest than [18F]THK-5317, but also its retention correlated with extra-hippocampal sub-regional atrophy rather than hippocampal subfields, proffering hence different underlying mechanisms of atrophy in early AD. The gene discussed is MAPT; the disease is Alzheimer disease.