BRCA1 and neoplasm: This may be due to a modulation of the adaptive immune system via recruitment of CD8+ T cells and suppression of regulatory T cells, which were found increased in miliary samples (Figure S2) [11] This observation may also be linked to higher levels of CD3+/CD8+ tumor-infiltrating lymphocytes found associated with mutated BRCA1/2 in HGSOC [76].