PBRM1 and renal cell carcinoma: None of the regions affected by amplifications or losses included canonical suppressor genes often mutated in RCC, such as VHL, PBRM1 SETD2, or BAP1. However, losses involved regions on chromosomal arms such as 1p, 9p, and 20q, which have already been described in the literature as frequently undergoing losses during tumor evolution.