To date, lncRNAs involved in multiple signalling pathways, such as the TGF-β, AKT/mTOR/p27, Hh, SIRT/P53, MAPK, and Wnt/β-catenin signalling pathways, have been demonstrated to regulate liver fibrosis [12,95] (Figure 3). This evidence concerns the gene AKT1 and Hepatic fibrosis.