SCARNA10 is a novel positive regulator of TGF-β signalling in hepatic fibrogenesis, and can aggravate liver fibrosis mainly by promoting TGF-β signalling via inhibition of polycomb repressive complex 2 (PRC2) binding to the promoters of genes involved in the TGF-β pathway [51]. The gene discussed is TGFB1; the disease is Hepatic fibrosis.