Notably, high levels of HOTTIP downregulate miR-148a, increase the expression levels of the miR-148a targets TGF-beta receptor type-1 (TGFBR1) and TGF-beta receptor type-2 (TGFBR2) and thus contribute to liver fibrosis [61]. The gene discussed is TGFBR1; the disease is Hepatic fibrosis.