MTOR and neoplasm: As a tumour-suppressor gene [74,75], GAS5 can act as a sponge platform for miR-23a and decrease miR-23a expression levels and then increase phosphate and tension homology deleted on chromosome ten (PTEN); this increase further affects the downstream PI3K/Akt/mammalian target of rapamycin (mTOR)/Snail signalling pathway, increasing E-cadherin expression levels and α-SMA and decreasing collagen I expression levels in rat HSCs [8].