CRP and inflammation of heart layer: The Jones criteria for rheumatic fever include major criteria (carditis, arthritis, chorea, erythema marginatum, subcutaneous nodules) and minor criteria (polyarthralgia, fever, prolonged PR interval, erythrocyte sedimentation rate (ESR) ≥60 mm, C-reactive protein (CRP) ≥3.0 mg/dL) [14].